chemokines – Communicable Diseases Research

CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19

Comment

Published on 2022-12-012023-07-10
Journal: The Journal of Infection
[Category] COVID19(2023년),

Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial

Article

Published on 2022-11-012022-11-15
Journal: Intensive care medicine
[Category] Fulltext, MERS, 바이오마커,

[키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19
[DOI] 10.1007/s00134-022-06869-w PMC 바로가기

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

Article

Published on 2022-10-052022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while
[DOI] 10.3389/fimmu.2022.861251 PMC 바로가기

Effect of Chemokine Gene Variants on Covid-19 Disease Severity

Article

Published on 2022-10-012023-07-09
Journal: Immunological investigations
[Category] COVID19(2023년),

[키워드] chemokines COVID-19 severity MCP-1.
[DOI] 10.1080/08820139.2022.2088383 PMC 바로가기

CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 Course

Article

Published on 2022-09-262022-11-15
Journal: International Journal of Molecular Sciences
[Category] 유전자 메커니즘, 진단,

Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications

Article

Published on 2022-09-022022-11-16
Journal: International Journal of Molecular Sciences
[Category] 유전자 메커니즘,

[키워드] application Autoimmune disease Cell Characteristics chemokines clinical Clinical applications Contact contribute COVID-19 Cytokines disease Diseases Effect Engineering Factor Growth factors homing immune immune cells immune disorders Immune homeostasis immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory property IMPROVE incurable Inflammatory diseases Inflammatory responses maintain mechanism mesenchymal stem cell mesenchymal stem cells (MSCs). MSC MSCs multifunctional Potential regenerative Regulation Secretome shown signaling molecules STEM stem cell systemic lupus erythematosus therapeutic strategy treat
[DOI] 10.3390/ijms231710023 PMC 바로가기

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease

주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다

Review

Published on 2022-09-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors Toll-like receptors. understanding variants of concern Variation viral infection viral infections VOCs
[DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review

Effectiveness, safety, and immunogenicity of half dose ChAdOx1 nCoV-19 COVID-19 Vaccine: Viana project

Article

Published on 2022-08-292022-11-15
Journal: Frontiers in Immunology
[Category] 진단,

[키워드] adverse event age and sex analyzed anti-SARS-CoV-2 baseline Biomarker booster dose ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chemiluminescence chemokines Concentration Controlled trial COVID-19 Cytokines death dose effective Effectiveness evaluated exclusion first dose Fractional dose Frequency geometric mean Growth factors healthcare worker Hospitalization immune response immunization immunoassay immunogenic immunogenicity incidence incidence rate increase in indicate individual individuals multiplex neutralizing antibody non-inferiority non-randomized plaque reduction neutralization plasma pre-immune primary endpoint PRNT Protein quantified RBD Receptor binding domain Registered reported RT-PCR Safe Safety second dose Serious Adverse Event seroconversion rate seronegative seropositive seropositive subject SUS Vaccine vaccine. Vaccines
[DOI] 10.3389/fimmu.2022.966416 PMC 바로가기

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Research article

Published on 2022-08-242022-10-05
Journal: The Lancet. Respiratory Medicine
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used
[DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article

Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort study

Article

Published on 2022-08-152022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단,

[키워드] abnormality acute infection acute respiratory syndrome anti-cellular antibodies anti-SARS-CoV-2 IgG antibodies antibody Antibody Response Antiviral baseline blood sample CD8 changes in characterized chemokine chemokines clinical cohort study coronavirus coronavirus disease COVID-19 Critical Critical disease Critical illness cytokine Cytokines defined Diagnosis evaluated feature flow cytometry Follow-up humoral humoral immune response Humoral response IgG IgGs IL-13 IL-2 IL-4 immune Immune profile immunological IP-10 key factor lymphocyte Lymphocytes lymphopenia lymphopenia. Measures Neutrophil extracellular trap outcome Patient patients with COVID-19 positive Primary outcome Quantitative recruitment regulatory T cells Research Result SARS-CoV-2 serum serum cytokine Serum level serum titer strongly related sustained T cell T cells the patient variable were assessed
[DOI] 10.3389/fimmu.2022.943563 PMC 바로가기